In Telum we believe nature is wise and we learn from the best properties of natural LYSins (LYS) to select them and construct from there, engineered phage lytic enzymes (EPLEs) with enhanced antimicrobial activities. NPLEs are phage produced by the phage during the infection cycle or form part of the virion structure, and are responsible for degradation of the peptidoglycan layer of the host bacterium in two important steps, lysis from without inyecting the genome of the phage and the lysis from withtin at the end of the lytic cycle to release new viral progeny.
EPLEs are engineered proteins result as combination of different activity modules, that confers the final synthetic product enhanced antimicrobial activity or resistance to hazardous environmental conditions, or an advantage when treating an infection.
FRANK are modifications of the most active candidates to create a consensus sequences using what is usually found in nature.
By connecting chemistry and physics of proteins with machine learning, Telum is leveraging the combinative potential of LYS and protein engineering to advance in new research.
