{"id":3195,"date":"2023-10-23T14:10:53","date_gmt":"2023-10-23T14:10:53","guid":{"rendered":"https:\/\/navarrahealthcluster.com\/partners\/leadartis\/"},"modified":"2025-08-05T10:46:31","modified_gmt":"2025-08-05T10:46:31","slug":"trimerbody-pharma","status":"publish","type":"page","link":"https:\/\/navarrahealthcluster.com\/en\/partners\/trimerbody-pharma\/","title":{"rendered":"Trimerbody Pharma"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3195\" class=\"elementor elementor-3195 elementor-3104\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-33e2406 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"33e2406\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1455f21\" data-id=\"1455f21\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-23431d8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"23431d8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0cb3585\" data-id=\"0cb3585\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-830fa71 elementor-widget elementor-widget-image\" data-id=\"830fa71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"455\" src=\"https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/Diseno-sin-titulo-17-1.png\" class=\"attachment-large size-large wp-image-10910\" alt=\"Trimerbody Pharma\" srcset=\"https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/Diseno-sin-titulo-17-1.png 1900w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/Diseno-sin-titulo-17-1-600x341.png 600w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/Diseno-sin-titulo-17-1-768x437.png 768w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/Diseno-sin-titulo-17-1-1536x873.png 1536w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d586c8f\" data-id=\"d586c8f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74780d6 elementor-widget elementor-widget-heading\" data-id=\"74780d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Trimerbody Pharma<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8cf9a5 elementor-widget elementor-widget-text-editor\" data-id=\"d8cf9a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Molecular engineering for health<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31918c6 elementor-widget elementor-widget-text-editor\" data-id=\"31918c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Immuno-oncology | Bispecific antibody | Immunostimulation | Tumour<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5ca4cf2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5ca4cf2\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a59c49d\" data-id=\"a59c49d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e321f0 elementor-widget elementor-widget-heading\" data-id=\"1e321f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Description<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1447707 elementor-widget elementor-widget-text-editor\" data-id=\"1447707\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div id=\"lipsum\">\n<div class=\"ewa-rteLine\">\n<div class=\"ewa-rteLine\">Trimerbody Pharma is a biopharmaceutical company dedicated to the development of multivalent and multispecific therapeutic antibodies, called Trimerbodies. Its antibodies are the result of internal R&amp;D and collaborations with leading research centres and prominent companies in the sector. <\/div>\n<div class=\"ewa-rteLine\"> <\/div>\n<div class=\"ewa-rteLine\">The company has multiple development programmes in various therapeutic areas, including immuno-oncology, a high-growth field for both companies and investors.<\/div>\n<div class=\"ewa-rteLine\"> <\/div>\n<div class=\"ewa-rteLine\">At Trimerbody Pharma, they develop next-generation antibodies for cutting-edge therapies against advanced cancers, with the aim of offering hope to future patients affected by cancers for which current treatments are insufficient.<\/div>\n<div class=\"ewa-rteLine\"> <\/div>\n<div class=\"ewa-rteLine\">Trimerbody\u00ae is a registered trademark and is covered by international patents.<\/div>\n<\/div>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a044a5 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-video\" data-id=\"1a044a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=imL6VR1ZyTU&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dddcd6 elementor-widget elementor-widget-image\" data-id=\"3dddcd6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"527\" src=\"https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/1646833636809443111-1638x1080.jpg\" class=\"attachment-large size-large wp-image-3498\" alt=\"\" srcset=\"https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/1646833636809443111-1638x1080.jpg 1638w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/1646833636809443111-600x396.jpg 600w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/1646833636809443111-768x506.jpg 768w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/1646833636809443111-1536x1013.jpg 1536w, https:\/\/navarrahealthcluster.com\/wp-content\/uploads\/1646833636809443111.jpg 2000w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a66c18 elementor-widget elementor-widget-heading\" data-id=\"3a66c18\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Featured projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb98bc2 elementor-widget elementor-widget-text-editor\" data-id=\"fb98bc2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div id=\"lipsum\">\n<ul>\n<li class=\"ewa-rteLine\">\n<p><strong>Milestone #1: In vitro validation of clinical candidate LEAD-452 and specific tumour localisation<\/strong><\/p>\n<p>Studies have shown that following intravenous administration, LEAD-452 demonstrates exceptional localisation in tumour tissue. Unlike competing IgG antibodies, ex vivo imaging confirmed that LEAD-452 localises exclusively in tumours, with no accumulation in vital organs such as the liver, spleen, kidneys, heart, or lungs. <\/p>\n<\/li>\n<li class=\"ewa-rteLine\">\n<p><strong>Milestone #2: Preclinical efficacy with complete tumour remission<\/strong><\/p>\n<p>Preclinical trials with LEAD-452 showed complete tumour regression in 100% of mice bearing a colorectal adenocarcinoma xenograft. A high level of CD8+ T cell infiltration was also observed in the treated tumours, reinforcing its immunomodulatory potential. <\/p>\n<\/li>\n<li class=\"ewa-rteLine\">\n<p><strong>Milestone #3: Specific memory immune response<\/strong><\/p>\n<p>Animals previously treated with LEAD-452 demonstrated resistance to re-challenge with colorectal tumour cells. This finding confirms LEAD-452\u2019s capacity to induce a protective and long-lasting memory immune response.<\/p>\n<\/li>\n<li class=\"ewa-rteLine\">\n<p><strong>Milestone #4: Scalable production and manufacturing process under GMP-like conditions<\/strong><\/p>\n<p>Using standard procedures, LEAD-452 was produced in CHO cells under GMP-like conditions, achieving yields of up to 2 g\/L.<\/p>\n<\/li>\n<li class=\"ewa-rteLine\">\n<div class=\"ewa-rteLine\"><strong>Milestone #5: Toxicity studies in non-human primates<\/strong><\/div>\n<div class=\"ewa-rteLine\"> <\/div>\n<div class=\"ewa-rteLine\">In GLP-like toxicity studies, LEAD-452 was administered intravenously in both single and repeated doses. It was well tolerated up to the maximum administered dose of 20 mg\/kg, with no evidence of hepatic or haematological toxicity, cytokine release syndrome, skin reactivity, or immunogenicity. <\/div>\n<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf833d2 elementor-widget elementor-widget-heading\" data-id=\"bf833d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/trimerbodypharma.com\/\">www.trimerbodypharma.com<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c47c92b elementor-shape-circle e-grid-align-left elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"c47c92b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-linkedin elementor-repeater-item-eccb05b\" href=\"https:\/\/www.linkedin.com\/company\/trimerbodypharma\/posts\/?feedView=all\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Linkedin<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-linkedin\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-x-twitter elementor-repeater-item-82ece8a\" href=\"https:\/\/x.com\/TrimerbodyPh\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">X-twitter<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-x-twitter\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-instagram elementor-repeater-item-713adca\" href=\"https:\/\/www.instagram.com\/trimerbodypharma\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Instagram<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-instagram\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Trimerbody Pharma Molecular engineering for health Immuno-oncology | Bispecific antibody | Immunostimulation | Tumour Description Trimerbody Pharma is a biopharmaceutical company dedicated to the development of multivalent and multispecific therapeutic antibodies, called Trimerbodies. Its antibodies are the result of internal R&amp;D and collaborations with leading research centres and prominent companies in the sector. The company [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2488,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3195","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Trimerbody Pharma &#8226; Navarra Health Cluster<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/navarrahealthcluster.com\/socias\/trimerbody-pharma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trimerbody Pharma &#8226; Navarra Health Cluster\" \/>\n<meta property=\"og:description\" content=\"Trimerbody Pharma Molecular engineering for health Immuno-oncology | Bispecific antibody | Immunostimulation | Tumour Description Trimerbody Pharma is a biopharmaceutical company dedicated to the development of multivalent and multispecific therapeutic antibodies, called Trimerbodies. 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